The MoCA may be able to preferentially detect executive dysfunction compared to the MMSE, but the MoCA has limited diagnostic accuracy for PD-MCI, and should not be used alone to make this diagnosis.Īssessment of cognitive disorders/dementia MCI (mild cognitive impairment) PD (Parkinson disease) PET (positron emission tomography).Ĭopyright © 2014 Elsevier Ltd. Results There were 32 cases (38.6) with abnormal MMSE score and 40 cases (51.8) with abnormal MoCA-B score. PD subjects with normal range MMSE but abnormal MoCA scores had evidence of caudate nucleus dopaminergic denervation and mild cognitive changes, predominantly in executive function. Both MoCA and MMSE had poor diagnostic accuracy for PD-MCI (65.3%) when using the Level 2 Movement Disorder Society Task Force definition. The MoCA-defined PD-MCI group had reduced performance in global cognition (t = 2.91, P = 0.0056), most significantly in executive function (t = 3.18, P = 0.002), as well as significant reduction in dorsal caudate nucleus dopaminergic innervation (t = 2.72, P = 0.009) compared to the PD without MCI group. Mini-Mental State Examination (MMSE) abnormal result 29.
Non-demented PD subjects underwent combined MoCA and MMSE, detailed cognitive testing and methyl-4-piperidinyl propionate acetylcholinesterase and dihydrotetrabenazine monoaminergic PET imaging.Įighteen subjects met MoCA PD-MCI criteria but had MMSE scores in the normal range, compared to 29 subjects with normal MoCA and MMSE scores. Montreal Cognitive Assessment (MoCA) abnormal result 26 (screening cutoff point). To compare neurochemical and neuropsychological functions in non-demented PD patients with mild cognitive impairment (PD-MCI) and without, as defined by MoCA (PD-MCI = MoCA<26). MoCA < 26 or abnormal result on another test in the battery (abnormal defined as 1.5 SD below age/ gender/ education matched norms). The MoCA's popularity likely reflects its ability to detect executive dysfunction, a relative deficiency of the Mini-Mental State Examination (MMSE). Concentration: You’ll be asked to spell five-letter words forward, then backward. Attention and short-term learning: You’ll be asked to recall a short list of items. The Montreal Cognitive Assessment (MoCA) is increasingly being used as a cognitive screening test in Parkinson disease (PD). Each test checks one or more of the following: Knowledge of time, place and person: You’ll be asked the current date, your location and your name.
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